What is the first action to change the layout of slide 5 to use the title and content layout?

To change the layout of slide 5 to the title and content layout, the first action you would take is to click the layout button in the Home tab. This button provides access to various slide layouts, including the title and content option. When you click on it, a dropdown menu appears that showcases the available layouts, allowing you to choose the one that fits your needs.

The layout button is a direct method to modify the selected slide's design, making it the most efficient first step in this process. The other choices involve different functionalities; for example, clicking the new slide button would create a new slide instead of modifying an existing one, pressing the ESC key would cancel any current action and not serve any purpose in this context, and navigating to slide 5 using thumbnails is merely a way to reach the desired slide but does not initiate any layout changes.